Body Recomposition
Losing fat is straightforward. Losing fat without losing the muscle underneath is the actual problem this stack addresses.
Choose your GLP agonist. The rest of the stack stays the same.
- Duration
- 12 weeks
- Suits
- Some experience
The schedule
Tirzepatide or Retatrutide
2.5 mg, titrating up- Frequency
- Once weekly
- When
- Same day each week
Start low. The gastrointestinal effects are dose-dependent and titrating slowly is the difference between tolerable and miserable.
CJC-1295 + Ipamorelin
200 mcg- Frequency
- 5 times per week
- When
- Before bed, at least 2 hours after food
This is the muscle-preservation half. Dropping it turns a recomposition into a straight cut.
MOTS-c
0.5–1 mg- Frequency
- 3 times per week
- When
- Morning
Studied for insulin sensitivity and exercise capacity.
Order this protocol
Everything in the schedule, in one order. Options where the protocol offers a choice.
View the protocol set →The problem this addresses
In an aggressive deficit the body does not politely take energy only from fat. Lean tissue goes too, and the more aggressive the deficit the worse that ratio gets. Someone who loses fifteen kilos and looks worse for it has usually lost a good share of it from muscle.
The GLP agonist drives the deficit. The growth hormone pairing is there to bias what the body gives up.
Choosing between Tirzepatide and Retatrutide
Tirzepatide is a dual agonist — GIP and GLP-1. Retatrutide adds a glucagon arm, which research associates with raised energy expenditure on top of appetite suppression. Retatrutide is earlier in its research history and costs more; Tirzepatide has the larger body of published trial data.
What the research supports
The metabolic agonists have substantial published clinical trial data behind them. The growth hormone secretagogues do not have equivalent evidence for muscle preservation during a deficit specifically — that pairing is a reasonable inference from mechanism rather than a demonstrated result.
Practical notes
Protein intake and resistance training do more for muscle retention than any compound here. A stack does not replace either.
Twelve weeks, then reassess. Titrate up slowly.
Schedules describe how these compounds are used in the research literature. They are not medical advice, and nothing here is for human consumption.