Protocols → The Engine Protocol

The Engine Protocol

Train longer. Gas out later. Fight better.

Emerging evidence4–10 weeksBest for: Muay Thai fighters, BJJ athletes, CrossFit, endurance athletes
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What this protocol does

MOTS-c is a mitochondrial-derived peptide — one of the first discovered — encoded in mitochondrial DNA and released as a systemic metabolic signal.

It activates AMPK, your cells' master energy sensor, telling your mitochondria to burn fat for fuel more efficiently and improving how your cells produce ATP.

The result in a training context is a higher aerobic ceiling — the point at which your energy system can no longer keep up with demand comes later. In Muay Thai terms: round 4 starts to feel like round 2 used to.

What's in this protocol

MOTS-c

Raises aerobic ceiling and fat oxidation

AMPK activation, mitochondrial efficiency

Dose: 5–10mg
Timing: Fasted, pre-training

What to expect

What's happening in your body

  1. Week 1

    AMPK activation begins immediately. Mitochondrial adaptation is gradual. Cellular energy efficiency improving at the biochemical level.

  2. Week 2

    Training sessions feel marginally less demanding at the same intensity. Cardio ceiling perceptibly higher.

  3. Weeks 3–4

    Main adaptation window. Fat oxidation efficiency measurably improved. Recovery between rounds and between sessions noticeably faster.

  4. Beyond 4

    Cumulative mitochondrial adaptation. Effects strongest when combined with consistent training stimulus.

What you actually feel

  1. Week 1

    Possibly nothing obvious. MOTS-c is not a stimulant — no acute sensation.

  2. Week 2

    Some athletes report better session quality — less of that feeling where the legs simply stop responding.

  3. Weeks 3–4

    The clearest window. Training capacity at week 4 is noticeably higher than week 1. This is best appreciated in retrospect.

  4. Beyond 4

    Continued improvement if training load is maintained.

Your dosing guide

MOTS-c 10mg — 5mg SC 3x per week (Mon/Wed/Fri), fasted, 30–45 minutes pre-training. Duration: 4 weeks.

For research purposes only. This is not medical advice.

Protocol FAQ

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For research purposes only · Not intended for human consumption · Keep out of reach of children