The Triple Protocol

Three receptors. One result.

Emerging evidence12+ weeksBest for: Experienced GLP-1 users wanting maximum effect, those who have plateaued on Semaglutide

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What this protocol does

Retatrutide is a triple GLP-1, GIP, and glucagon receptor agonist — the most advanced metabolic compound currently available in research.

GLP-1 and GIP work as in Tirzepatide. The glucagon receptor component adds direct thermogenic and visceral fat targeting effects.

Three simultaneous mechanisms produce outcomes that single and dual agonists cannot match at equivalent doses. This is the frontier of GLP-1 research.

What's in this protocol

Retatrutide

Maximum metabolic effect across three receptors

GLP-1 + GIP + glucagon receptor agonism

Dose: 2–12mg

Timing: Once weekly SC

What to expect

What's happening in your body

Week 1

Three receptors activated. Appetite reduction and increased energy expenditure begin.

Week 2

Adaptation phase — slower ramp than other GLP-1s. Body adjusting to triple mechanism.

Weeks 3–4

Strong fat loss including visceral. Thermogenic effect noticeable.

Beyond 4

Continued progress at doses other GLP-1s cannot match.

Week 1
Three receptors activated. Appetite reduction and increased energy expenditure begin.
Week 2
Adaptation phase — slower ramp than other GLP-1s. Body adjusting to triple mechanism.
Weeks 3–4
Strong fat loss including visceral. Thermogenic effect noticeable.
Beyond 4
Continued progress at doses other GLP-1s cannot match.

What you actually feel

Week 1

Strong appetite reduction, slightly warmer than baseline (glucagon component).

Week 2

Adaptation — side effects easing.

Weeks 3–4

Rapid visible composition changes.

Beyond 4

Sustained transformation if escalated patiently.

Week 1
Strong appetite reduction, slightly warmer than baseline (glucagon component).
Week 2
Adaptation — side effects easing.
Weeks 3–4
Rapid visible composition changes.
Beyond 4
Sustained transformation if escalated patiently.

Your dosing guide

Start 2mg per week. Escalate slowly — 2 → 4 → 6 → 8mg over 16 weeks minimum.

For research purposes only. This is not medical advice.

Protocol FAQ

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The Recomposition Protocol

The science behind the transformation.

Best for: Anyone targeting significant fat loss, expats and professionals, first-time GLP-1 users starting at the most effective compound

Strong evidence

The Precision Protocol

Steady. Proven. Effective.

Best for: Conservative first-time GLP-1 users, those who prefer the longest clinical track record

Strong evidence

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@siamlabs · siamlabs.co

For research purposes only · Not intended for human consumption · Keep out of reach of children